Levodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease
نویسندگان
چکیده
Parkinson’s disease, the second most common neurodegenerative disease in world, develops due to decreased dopamine levels basal ganglia. Levodopa, a precursor used treatment of can be as drug delivery system. This study presents an approach use 3D-printed levodopa-loaded neural tissue scaffolds produced with polylactic acid (PLA) and chitosan (CS) for disease. Surface morphology pore sizes were examined by scanning electron microscopy (SEM). Average 100–200 µm found ideal engineering scaffolds, allowing cell penetration but not drastically altering mechanical properties. It was observed that swelling weight loss behaviors increased after addition CS PLA. Levodopa released from controlled manner 14 days, according Fickian diffusion mechanism. Mesenchymal stem cells (hAD-MSCs) derived human adipose MTT analysis, fluorescence SEM studies confirmed adequate biocompatibility. Overall, obtained results show PLA/CS have alternative levodopa system applications.
منابع مشابه
An Overview of the Application of Poly(lactic-co-glycolic) Acid (PLGA)-Based Scaffold for Drug Delivery in Cartilage Tissue Engineering
Poly(lactic-co-glycolic) acid (PLGA) has attracted a considerable amount of interest for biomedical application due to its biocompatibility, tailored biodegradation rate (depending on the molecular weight and copolymer ratio), approval for clinical use in humans by the U.S. Food and Drug Administration (FDA), the potential to change surface properties to create better interaction with biologica...
متن کاملvancomycin loaded chitosan beads as a drug delivery system for local antibiotic delivery in some infections
متن کامل
Vincristine loaded niosomes as an effective drug delivery system for lymphoma
Aim and Background: Vincristine is a herbal anticancer drug which is used to treat a wide range of cancers such as lymphoma. Niosomes are important drug carriers. The aim of this study was to prepare PEGylated niosomal form of vincristine in order to increase its efficacy in lymph nodes’ cancer. Material and Methods: PEGylated niosomal vincristine (PEG-nVCR) was prepared by thin film hydrat...
متن کاملAu Nanoparticle Loaded with 6-Thioguanine Anticancer Drug as a New Strategy for Drug Delivery
In this study we suggested a new strategy for drug delivery of 6-thioguanine (6-TG) as a cancer drug by loading of this thiolic drug at a surface of Au nanoparticles. For this goal, we synthesized Au nanoparticle (Au/NPs) by reduction of tetrachloroauric (III) acid solutions by sodium borohydride and characterized Au/NPs by X-ray powder diffraction (XRD), dynamic light scattering (DLS), Ultravi...
متن کاملPoly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges
Numerous Scientists have discovered the procedure of nanotechnology, explicitlynanofibers, asdrug delivery systems for transdermal uses. Nanofibers canbe used to deliver drugs and are capable of controlled release for a continued periodof time. Poly (Lactic Acid) (PLA) is the lastly interesting employed synthetic polymer in biomedical application owing to its well categorized biodegradable prop...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Applied sciences
سال: 2021
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app112210727